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Metaxalone-d3

CAT: 0804-HY-B0678S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0678S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Metaxalone-d3 is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia[1][2][3][4].
CAS Number
1192812-66-0
UNSPSC
12352005
Target
Isotope-Labeled Compounds; NF-κB; PGC-1α
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
98.0
Solubility
10 mM in DMSO|DMSO : ≥ 100mg/mL
Smiles
CC1=C([2H])C(C)=C([2H])C(OCC2OC(NC2)=O)=C1[2H]
Molecular Formula
C12H12D3NO3
Molecular Weight
224.27
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]http://en.wikipedia.org/wiki/Metaxalone|[3]Stanko JR. Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner. Cranio. 1990 Jul;8 (3) :234-43.|[4]Pallio G, et al. MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells. Int J Mol Sci. 2021;22 (16) :8425.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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