Metaxalone-d6

• Target:

  NF-?B

• Related Pathways:

  NF-?B|||Metabolism

• Bioactivity:

  Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-?, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

• Smiles:

  C(OC1=CC(C([2H])([2H])[2H])=CC(C([2H])([2H])[2H])=C1)C2OC(=O)NC2

• Molecular Formula:

  C12H9D6NO3

• Molecular Weight:

  227.29

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1189944-95-3