Phenytoin

• Description :

  Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

• Product Name Alternative :

  5,5-Diphenylhydantoin

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H351, H360

• Target :

  Sodium Channel; Virus Protease

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/phenytoin.html

• Purity :

  99.95

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1NC(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O

• Molecular Formula :

  C15H12N2O2

• Molecular Weight :

  252.27

• Precautions :

  H302, H351, H360

• References & Citations :

  [1]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[2]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[3]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.|[4]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14 (1) :13.|[5]Assaggaf MA, et al. Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. Am J Pathol. 2015 Jun;185 (6) :1588-99.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Oxid Med Cell Longev. 2022 Mar 28;2022:8538296.|Regen Ther. 2023 Jul 6:24:201-210.|Int Immunopharmacol. 2023 Feb:115:109706.|University of Glasgow. School of Cancer Sciences.

• CAS Number :

  [57-41-0]