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Phenytoin

CAT: 0804-HY-B0448-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0448-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].
CAS Number
57-41-0
Product Name Alternative
5,5-Diphenylhydantoin
UNSPSC
12352005
Hazard Statement
H302, H351, H360
Target
Sodium Channel; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/phenytoin.html
Purity
99.95
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O
Molecular Formula
C15H12N2O2
Molecular Weight
252.27
Precautions
H302, H351, H360
References & Citations
[1]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[2]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[3]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.|[4]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14 (1) :13.|[5]Assaggaf MA, et al. Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. Am J Pathol. 2015 Jun;185 (6) :1588-99.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Oxid Med Cell Longev. 2022 Mar 28;2022:8538296.|Regen Ther. 2023 Jul 6:24:201-210.|Int Immunopharmacol. 2023 Feb:115:109706.|University of Glasgow. School of Cancer Sciences.

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