Phenytoin-15n2,13c

Phenytoin-15n2,13c

• CAS Number: 78213-26-0
• UNSPSC Description: Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].
• Target Antigen: Sodium Channel; Virus Protease
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Membrane Transporter/Ion Channel
• Applications: COVID-19-anti-virus
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/phenytoin-15n2-13c.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(C2=CC=CC=C2)(C3=CC=CC=C3)[15NH][13C]([15NH]1)=O
• Molecular Weight: 255.25
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64.|[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[4]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51(5): p. 1379-87.|[5]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 2714(1):13.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported