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Ambrisentan-d10

CAT: 0804-HY-13209SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13209SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ambrisentan-d10 (BSF 208075-d10; LU 208075-d10) is the deuterium labled Ambrisentan. Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
CAS Number
1046116-27-1
Product Name Alternative
BSF 208075-d10; LU 208075-d10
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
CC1=NC(O[C@H](C(O)=O)C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])OC)=NC(C)=C1
Molecular Formula
C22H12D10N2O4
Molecular Weight
388.48
References & Citations
[1]Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8 (22) :933-41.|[2]Lisk C, et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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