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Ketoprofen-d4

CAT: 0804-HY-B0227S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0227S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ketoprofen-d4 is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
CAS Number
1219805-29-4
Product Name Alternative
RP-19583-d4
UNSPSC
12352005
Target
Apoptosis; COX
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
98.74
Solubility
10 mM in DMSO|DMSO : ≥ 100mg/mL|H2O : 0.1mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1)C2=CC(C(C([2H])([2H])[2H])([2H])C(O)=O)=CC=C2
Molecular Formula
C16H10D4O3
Molecular Weight
258.31
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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