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Ketoprofen-13C6

CAT: 0804-HY-B0227S3Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0227S3Size:1 Each
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Description
Ketoprofen-13C6 (RP-19583-13C6) is 13C labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) . which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].
CAS Number
1261392-46-4
Product Name Alternative
RP-19583-13C6
UNSPSC
12352005
Target
COX; Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Cancer
Smiles
O=C([13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1)C2=CC(C(C)C(O)=O)=CC=C2
Molecular Formula
C10 13C6H14O3
Molecular Weight
260.24
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7. |[3]NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472 (5) :583-596. |[4]Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101 (12) :11321-11329.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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