Ketoprofen (sodium)

• Description :

  Ketoprofen (RP-19583) sodium is a non-steroidal anti-inflammatory agent. Ketoprofen sodium can inhibit the activity of Cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) . Ketoprofen is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

• CAS Number :

  [57495-14-4]

• Product Name Alternative :

  19583 RP-Na

• UNSPSC :

  12352005

• Target :

  COX

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology

• Smiles :

  O=C(C(C)C1=CC(C(C2=CC=CC=C2)=O)=CC=C1)O[Na]

• Molecular Formula :

  C16H13NaO3

• Molecular Weight :

  276.26

• References & Citations :

  [1]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7.|[2]NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472 (5) :583-596.|[3]Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101 (12) :11321-11329.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported