Ketoprofen (sodium)

• Description:

  Ketoprofen (RP-19583) sodium is a non-steroidal anti-inflammatory agent. Ketoprofen sodium can inhibit the activity of Cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) . Ketoprofen is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

• Product Name Alternative:

  19583 RP-Na

• UNSPSC:

  12352005

• Target:

  COX

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology

• Smiles:

  O=C(C(C)C1=CC(C(C2=CC=CC=C2)=O)=CC=C1)O[Na]

• Molecular Formula:

  C16H13NaO3

• Molecular Weight:

  276.26

• References & Citations:

  [1]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7.|[2]NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472 (5) :583-596.|[3]Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101 (12) :11321-11329.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [57495-14-4]