Ketoprofen (lysinate)

CAT: 0804-HY-B0227ASize: 1 EachDry Ice: NoHazardous: No

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Description

Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) . which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

CAS Number

57469-78-0

Product Name Alternative

RP-19583 (lysinate)

UNSPSC

12352005

Hazard Statement

H301

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/ketoprofen-lysinate.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CCCCN)C(O)=O.O=C(O)C(C)C1=CC=CC(C(C2=CC=CC=C2)=O)=C1

Molecular Formula

C22H28N2O5

Molecular Weight

400.47

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7.|[2]NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472 (5) :583-596. |[3]Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101 (12) :11321-11329.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

COX-1; COX-2

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HY-B0227-01	Ketoprofen
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HY-131118-01	Desmethyl Ketoprofen
HY-B2137-01	S- (+) -Ketoprofen
HY-B0227S-01	Ketoprofen-d3
HY-CE01651	Ketoprofen-CoA
HY-B0227S3	Ketoprofen-13C6
HY-W322573-01	(R) -Ketoprofen
HY-B0227R-01	Ketoprofen (Standard)
HY-167630-01	Ketoprofen (sodium)

Alternative Products

Catalog	Name
281128	Ketoprofen Lysinate
AR-K01666-01	Ketoprofen D-Lysinate
452163-01	Ibuprofen Lysinate
GTR19199538-01	Alclofenac lysinate
GTR19223063-01	N-Acetylcysteine lysinate
T25511-01	Hydrocortisone-21-lysinate
AR-I04334-01	Ibuprofen L-lysinate
MBS340233-01	Ketoprofen

Ketoprofen (lysinate)

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