Amphotericin B-13C6

Amphotericin B-13C6 is 13C labeled Amphotericin B. Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

12352005

Antibiotic; Bacterial; Fungal; Isotope-Labeled Compounds; Parasite

Isotope-Labeled Compounds

Anti-infection; Others

Cancer-programmed cell death

Cancer

https://www.medchemexpress.com/amphotericin-b-13c6.html

10 mM in DMSO

C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[13C@]2([H])O[13C@H]([13CH3])[13C@@H](O)[13C@H](N)[13C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3

C41 13C6H73NO17

930.03

[1]Sau K, et al. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem. 2003 Sep 26;278 (39) :37561-8. Epub 2003 Jul 14.|[2]Barwicz J, et al. The effect of aggregation state of amphotericin-B on its interactions with cholesterol- or ergosterol-containing phosphatidylcholine monolayers. Chem Phys Lipids. 1997 Feb 28;85 (2) :145-55.|[3]Ramos H, et al. Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions. J Membr Biol. 1996 Jul;152 (1) :65-75.|[4]Demaimay R, et al. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J Gen Virol. 1994 Sep;75 (Pt 9) :2499-503.|[5]Adams ML, et al. Amphotericin B encapsulated in micelles based on poly (ethylene oxide) -block-poly (L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules. 2003 May-Jun;4 (3) :750-7.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Room temperature

Isotope-Labeled Compounds