Amphotericin X1

• UNSPSC Description:

  Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1].

• Target Antigen:

  Fungal

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/amphotericin-x1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CO[C@](C[C@@H]1O)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(O[C@H]([C@@H]([C@@H]2O)C)C)=O)O)O)O)O)O)O[C@](C[C@H](/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H]2C)O[C@@](O[C@@H]3C)([H])[C@H]([C@H]([C@@H]3O)N)O)([H])[C@@H]1C(O)=O

• Molecular Weight:

  938.11

• References & Citations:

  [1]Taylor AW, et al. Synthesis and antifungal selectivity of new derivatives of amphotericin B modified at the C-13 position. J Antibiot (Tokyo). 1993 Mar;46(3):486-93.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  136135-57-4