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Amphotericin B methyl ester

CAT: 0804-HY-135327-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135327-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250) . Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].
CAS Number
36148-89-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fungal; HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/amphotericin-b-methyl-ester.html
Purity
96.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC([C@H]1[C@@]2([H])O[C@](O)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(O[C@H]([C@@H]([C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@]3([H])[C@H]([C@H]([C@H](O)[C@@H](C)O3)N)O)C2)C)C)=O)O)O)O)O)O)C[C@@H]1O)=O
Molecular Formula
C48H75NO17
Molecular Weight
938.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82 (19) :9776-81.|[2]Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10 (4) :687-90.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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