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Amphotericin B (trihydrate)

CAT: 0804-HY-B0221ASize: 1 EachDry Ice: NoHazardous: No
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Description
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity[1][2].
CAS Number
1202017-46-6
UNSPSC
12352005
Target
Antibiotic; Bacterial; Fungal; Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/amphotericin-b-trihydrate.html
Solubility
10 mM in DMSO
Smiles
C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3.[H]O[H].[H]O[H].[H]O[H]
Molecular Formula
C47H79NO20
Molecular Weight
978.12
References & Citations
[1]A Lemke, et al. Amphotericin B Appl Microbiol Biotechnol. 2005 Aug;68 (2) :151-62.|[2]Andreza Rochelle do Vale Morais, et al. In-vitro and in-vivo antileishmanial activity of inexpensive Amphotericin B formulations: Heated Amphotericin B and Amphotericin B-loaded microemulsion. Exp Parasitol. 2018 Sep;192:85-92.|[3]Ramos H, et al. Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions. J Membr Biol. 1996 Jul;152 (1) :65-75.|[4]Demaimay R, et al. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J Gen Virol. 1994 Sep;75 (Pt 9) :2499-503.|[5]Adams ML, et al. Amphotericin B encapsulated in micelles based on poly (ethylene oxide) -block-poly (L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules. 2003 May-Jun;4 (3) :750-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Leishmania; Plasmodium

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