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Trandolaprilate (hydrate)

CAT: 0804-HY-A0116ASize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0116ASize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].
CAS Number
951393-55-8
Product Name Alternative
Trandolaprilat (hydrate) ; RU 44403 (hydrate)
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/trandolaprilate-hydrate.html
Purity
97.30
Solubility
DMSO : 4.3 mg/mL (ultrasonic; warming)
Smiles
O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O.O
Molecular Formula
C22H32N2O6
Molecular Weight
420.50
References & Citations
[1]Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517. |[2]Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206 (2) :367-72.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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