Trandolaprilate

• Description :

  Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].

• Product Name Alternative :

  Trandolaprilat; RU 44403

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/trandolaprilate.html

• Purity :

  99.42

• Solubility :

  DMSO : 125 mg/mL (ultrasonic) |H2O : 13.33 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O

• Molecular Formula :

  C22H30N2O5

• Molecular Weight :

  402.48

• Precautions :

  H360

• References & Citations :

  [1]Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206 (2) :367-72. |[2]Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [87679-71-8]