Trandolaprilate

CAT: 0804-HY-A0116-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0116-01Size:1 mg
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Description
Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].
CAS Number
[87679-71-8]
Product Name Alternative
Trandolaprilat; RU 44403
UNSPSC
12352005
Hazard Statement
H360
Target
Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/trandolaprilate.html
Purity
99.42
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 13.33 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O
Molecular Formula
C22H30N2O5
Molecular Weight
402.48
Precautions
H360
References & Citations
[1]Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206 (2) :367-72. |[2]Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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