(+)-Catechin hydrate

• UNSPSC Description:

  (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

• Target Antigen:

  COX

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/__addition__-Catechin_hydrate.html

• Purity:

  99.59

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  OC1=CC(O)=C(C[C@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)C3=C1.[xH2O]

• References & Citations:

  [1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.|[2]Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167.|[3]Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259.Autophagy. 2021 Apr;17(4):872-887.|Phytomedicine. 2024 May 12:130:155733.|ACS Omega. 2024 May 17.|Acta Pharm Sin B. 2021 Jan;11(1):143-155.|Antioxidants (Basel). 2024 Jul 28;13(8):909.|Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303.|Biochem Biophys Res Commun. 2023 Dec 20, 687, 149196.|Biomaterials. 2021, 120952.|Int J Insect Sci. 2018 Feb 28;10:1179543318758409.|Plant Cell Physiol. 2020 Feb 1;61(2):318-330.|Plants. 2021, 10(11), 2525.|SSRN. 2023 Jul 14.|Toxicol Appl Pharmacol. 2024 Jul 14:490:117036.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  225937-10-0