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Monomethyl auristatin E intermediate-2

CAT: 0804-HY-49413Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-49413Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Monomethyl auristatin E intermediate-2 is an intermediate reagent in the synthesis of Monomethyl auristatin E. Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
CAS Number
3026596-62-0
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin
Type
ADC Related
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-2.html
Purity
97.54
Solubility
10 mM in DMSO
Smiles
OC([C@H](C)[C@@H](OCOC)[C@H]1N(C(OC(C)(C)C)=O)CCC1)=O
Molecular Formula
C15H27NO6
Molecular Weight
317.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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