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Calcifediol-d6 (monohydrate)

CAT: 0804-HY-32351ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-32351ASSize:1 mg
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Description
Calcifediol-d6 monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels[1][2][3].
CAS Number
2483831-70-3
Product Name Alternative
25-hydroxy Vitamin D3-d6 (monohydrate)
UNSPSC
12352211
Hazard Statement
H301, H330, H372
Target
Endogenous Metabolite; Isotope-Labeled Compounds; VD/VDR
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Purity
97.50
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])([H])/C(CCC1)=C/C=C3C(CC[C@@H](C\3)O)=C.[H]O[H]
Molecular Formula
C27H40D6O3
Molecular Weight
424.69
Precautions
H301, H330, H372
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.|[3]Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38 (6) :BSR20180595.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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