Calcifediol

• Description:

  Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels[1][2][3].

• Product Name Alternative:

  25-Hydroxy Vitamin D3

• UNSPSC:

  12352211

• Hazard Statement:

  H301

• Target:

  Endogenous Metabolite; VD/VDR

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Calcifediol.html

• Purity:

  99.94

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC3

• Molecular Formula:

  C27H44O2

• Molecular Weight:

  400.64

• Precautions:

  H301

• References & Citations:

  [1]Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.|[2]Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38 (6) :BSR20180595.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite

• Citation 01:

  Front Pharmacol. 2020 Mar 31;11:200.|Int Immunopharmacol. 2023 Sep:122:110558.|Int J Mol Sci. 2017 Dec 19;18 (12) . pii: E2764.|Int J Mol Sci. 2025 Mar 25;26 (7) :2985.|J Sep Sci. 2025 Apr;48 (4) :e70130.|Nat Chem Biol. 2022 Nov;18 (11) :1196-1203.|Proc Natl Acad Sci U S A. 2022 Apr 12;119 (15) :e2117004119.|Ther Adv Endocrinol Metab. 2020 Oct 20:11:2042018820958295.|Virol Sin. 2024 Aug 19:S1995-820X (24) 00134-2.|Sci Rep. 2022 Feb 22;12 (1) :3014.

• CAS Number:

  [19356-17-3]