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Calcifediol

CAT: 804-HY-32351-01Size: 1 mgDry Ice: NoHazardous: No
1 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels[1][2][3].
CAS Number
[19356-17-3]
Product Name Alternative
25-Hydroxy Vitamin D3
UNSPSC
12352211
Hazard Statement
H301
Target
Endogenous Metabolite; VD/VDR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Calcifediol.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC3
Molecular Formula
C27H44O2
Molecular Weight
400.64
Precautions
H301
References & Citations
[1]Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.|[2]Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38 (6) :BSR20180595.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Citation 01
Front Pharmacol. 2020 Mar 31;11:200.|Int Immunopharmacol. 2023 Sep:122:110558.|Int J Mol Sci. 2017 Dec 19;18 (12) . pii: E2764.|Int J Mol Sci. 2025 Mar 25;26 (7) :2985.|J Sep Sci. 2025 Apr;48 (4) :e70130.|Nat Chem Biol. 2022 Nov;18 (11) :1196-1203.|Proc Natl Acad Sci U S A. 2022 Apr 12;119 (15) :e2117004119.|Ther Adv Endocrinol Metab. 2020 Oct 20:11:2042018820958295.|Virol Sin. 2024 Aug 19:S1995-820X (24) 00134-2.|Sci Rep. 2022 Feb 22;12 (1) :3014.

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