Calcifediol (monohydrate)

• UNSPSC Description:

  Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels[1][2][3].

• Target Antigen:

  Endogenous Metabolite; VD/VDR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease

• Purity:

  99.89

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC3.O

• Molecular Weight:

  418.65

• References & Citations:

  [1]Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.|[2]Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38(6):BSR20180595.Sci Rep. 2022 Feb 22;12(1):3014.|Front Pharmacol. 2020 Mar 31;11:200.|Int Immunopharmacol. 2023 Jun 30;122:110558.|Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764.|Nat Chem Biol. 2022 Aug 18.|Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119.|Ther Adv Endocrinol. 2020 Oct 20. |Virol Sin. 2024 Aug 19:S1995-820X(24)00134-2.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  Launched

• CAS Number:

  63283-36-3