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Org-12962 (hydrochloride)

CAT: 0804-HY-21994Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-21994Size:1 Each
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Description
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2].
CAS Number
210821-63-9
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/org-12962-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F.[H]Cl
Molecular Formula
C10H12Cl2F3N3
Molecular Weight
302.12
References & Citations
[1]Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128 (1) :13-20.|[2]Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8 (3) :161-8.|[3]Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263 (1-2) :113-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin