AM-8553

• Description:

  AM-8553 is a MDM2/p53 inhibitor (KD: 0.4 nM for MDM2) . AM-8553 has anti-tumor activity[1]

• UNSPSC:

  12352005

• Target:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/am-8553.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C[C@]1(C)C(N([C@@H](CC)[C@@H](O)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O

• Molecular Formula:

  C25H29Cl2NO4

• Molecular Weight:

  478.41

• References & Citations:

  [1]Bernard D, et al. AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development. J Med Chem. 2012 Jun 14;55 (11) :4934-5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1352064-70-0]