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AM-8553

CAT: 0804-HY-18052Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18052Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM-8553 is a MDM2/p53 inhibitor (KD: 0.4 nM for MDM2) . AM-8553 has anti-tumor activity[1]
CAS Number
1352064-70-0
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/am-8553.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C[C@]1(C)C(N([C@@H](CC)[C@@H](O)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O
Molecular Formula
C25H29Cl2NO4
Molecular Weight
478.41
References & Citations
[1]Bernard D, et al. AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development. J Med Chem. 2012 Jun 14;55 (11) :4934-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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