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Itraconazole-d9

CAT: 0804-HY-17514S2Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17514S2Size:1 mg
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Description
Itraconazole-d9 is the deuterium labeled Itraconazole[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor[2][3][4][5].
CAS Number
1309272-50-1
Product Name Alternative
R51211-d9
UNSPSC
12352005
Target
Antibiotic; Autophagy; Bacterial; Cytochrome P450; Fungal; Hedgehog
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection
Purity
97.86
Solubility
DMSO : 6.25 mg/mL (ultrasonic; warming)
Smiles
O=C(N(N=C1)C(C([2H])([2H])[2H])([2H])C([2H])([2H])C([2H])([2H])[2H])N1C(C=C2)=CC=C2N(CC3)CCN3C(C=C4)=CC=C4OC[C@@H](CO5)O[C@]5(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7
Molecular Formula
C35H29D9Cl2N8O4
Molecular Weight
714.69
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell, 2010. 17 (4) : p. 388-99.|[3]Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2 (4) : p. 263-70.|[4]Pace JR, et al. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 Apr 28;59 (8) :3635-49.|[5]Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017;140:37-44.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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