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Itraconazole-d5

CAT: 0804-HY-17514SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17514SSize:1 mg
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Description
Itraconazole-d5 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].
CAS Number
1217510-38-7
Product Name Alternative
R51211-d5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Autophagy; Cytochrome P450; Fungal; Hedgehog
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Purity
99.55
Solubility
DMF : ≥ 0.5mg/mL|DMSO : ≥ 0.5mg/mL
Smiles
ClC1=C(C=CC(Cl)=C1)[C@@]2(O[C@@H](COC3=CC=C(N4CCN(C5=CC=C(N(C=NN6C(C)C([2H])([2H])C([2H])([2H])[2H])C6=O)C=C5)CC4)C=C3)CO2)CN7C=NC=N7
Molecular Formula
C35H33D5Cl2N8O4
Molecular Weight
710.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell, 2010. 17 (4) : p. 388-99.|[3]Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2 (4) : p. 263-70.|[4]Pace JR, et al. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 Apr 28;59 (8) :3635-49.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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