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Nelonicline (citrate)

CAT: 0804-HY-16748ASize: 1 EachDry Ice: NoHazardous: No
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Description
Nelonicline (ABT-126) citrate is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM) . Nelonicline citrate is used for the research of shizophrenia and Alzheimer's disease[1][2][3].
CAS Number
1026136-84-4
Product Name Alternative
ABT-126 (citrate)
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nelonicline-citrate.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CC(O)(CC(O)=O)C(O)=O.[C@@H]1([C@H]2C[C@H](C3)C[C@@H]1C[N@]3C2)OC4=NN=C(C5=CC=CC=C5)S4
Molecular Formula
C23H27N3O8S
Molecular Weight
505.54
References & Citations
[1]Zhang D, et al. α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Mov Disord. 2015;30 (14) :1901-1911.|[2]Haig G, et al. The α7 Nicotinic Agonist ABT-126 in the Treatment of Cognitive Impairment Associated with Schizophrenia in Nonsmokers: Results from a Randomized Controlled Phase 2b Study. Neuropsychopharmacology. 2016;41 (12) :2893-2902.|[3]Gault LM, et al. ABT-126 monotherapy in mild-to-moderate Alzheimer's dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension. Alzheimers Res Ther. 2016;8 (1) :44. Published 2016 Oct 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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