Nelonicline

CAT: 0804-HY-16748-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-16748-01Size:1 mg

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Description

Nelonicline (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM) . Nelonicline is used for the research of shizophrenia and Alzheimer's disease[1][2][3].

CAS Number

1026134-63-3

Product Name Alternative

ABT-126

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Nelonicline.html

Purity

99.82

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[C@@H]1([C@H]2C[C@H](C3)C[C@@H]1C[N@]3C2)OC4=NN=C(C5=CC=CC=C5)S4

Molecular Formula

C17H19N3OS

Molecular Weight

313.42

References & Citations

[1]Zhang D, et al. α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Mov Disord. 2015;30 (14) :1901-1911.|[2]Haig G, et al. The α7 Nicotinic Agonist ABT-126 in the Treatment of Cognitive Impairment Associated with Schizophrenia in Nonsmokers: Results from a Randomized Controlled Phase 2b Study. Neuropsychopharmacology. 2016;41 (12) :2893-2902.|[3]Gault LM, et al. ABT-126 monotherapy in mild-to-moderate Alzheimer's dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension. Alzheimers Res Ther. 2016;8 (1) :44. Published 2016 Oct 18.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

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Nelonicline

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