Sildenafil (citrate)

• UNSPSC Description:

  Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.

• Target Antigen:

  Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Autophagy;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Sildenafil-citrate.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic)

• Smiles:

  O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1.O=C(CC(C(O)=O)(O)CC(O)=O)O

• Molecular Weight:

  666.70

• References & Citations:

  [1]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7.|[2]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40.|[3]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95.|[4]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11.Sci Rep. 2020 Oct 2;10(1):16383.|ACS Omega. 2020 Nov 15;5(46):29935-29942.|Biochem Biophys Res Commun. 2021 Feb 12;547:9-14.|Biochim Biophys Acta Mol Basis Dis. 2024 Jan 5:167018.|Bioeng Transl Med. 2023 Jul 2.|Biomed Chromatogr. 2024 Jun 5:e5925.|Br J Pharmacol. 2024 Sep 10.|Int J Mol Sci. 2022 Jun 20;23(12):6860.|Physiol Rep. 2023 Jan;11(1):e15549.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  171599-83-0