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Sildenafil (citrate)

CAT: 0804-HY-15025A-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15025A-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
CAS Number
171599-83-0
Product Name Alternative
UK-92480 (citrate)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Sildenafil-citrate.html
Purity
99.86
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)
Smiles
O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1.O=C(CC(C(O)=O)(O)CC(O)=O)O
Molecular Formula
C28H38N6O11S
Molecular Weight
666.70
Precautions
H315, H319, H335
References & Citations
[1]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10 (11) :2790-7.|[2]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep;124 (17) :2733-40.|[3]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13 (1) :95.|[4]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33 (2) :204-11.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PDE5
Citation 01
Phytother Res. 2025 Mar;39 (3) :1549-1564.|Sci Rep. 2020 Oct 2;10 (1) :16383.|ACS Environ Au. 2025 Aug 8.|ACS Omega. 2020 Nov 15;5 (46) :29935-29942.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Biochem Biophys Res Commun. 2021 Apr 2:547:9-14.|Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870 (3) :167018.|Bioeng Transl Med. 2023 Jul 2;8 (5) :e10568.|Biomed Chromatogr. 2024 Jun 5:e5925.|Br J Pharmacol. 2024 Dec;181 (23) :4920-4936.|Int J Mol Sci. 2022 Jun 20;23 (12) :6860.|J Nat Med. 2025 Sep;79 (5) :1154-1166.|Nature. 2025 Sep;645 (8079) :244-253.|Physiol Rep. 2023 Jan;11 (1) :e15549.|Phytomedicine. 2025 Sep 25:148:157334.

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