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Zharp1-163

CAT: 0013-GTR19273210-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273210-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zharp1-163 is a dual inhibitor of ferroptosis and necroptosis. It effectively blocks ferroptosis by reducing reactive oxygen species (ROS) levels and inhibits necroptosis by potently and selectively targeting RIPK1 kinase activity (KD = 240 nM; IC50 = 406.1 nM) . Zharp1-163 suppresses the cellular activation of RIPK1, RIPK3, and MLKL induced by necroptosis stimuli. The compound significantly alleviates TNF-α-induced systemic inflammatory syndrome, preventing TNF-α-induced lethality and hypothermia in mice. Additionally, Zharp1-163 mitigates acute kidney injury related to necroptosis and ferroptosis in models induced by cisplatin and ischemia-reperfusion. Zharp1-163 is applicable for studying diseases linked to cellular death pathways, such as kidney diseases.
Storage Conditions
-20°C
Notes
For research use only.

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