RGH-560

CAT: 0804-HY-149776Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149776Size:1 Each
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Description
RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1].
CAS Number
[2408799-43-7]
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rgh-560.html
Solubility
10 mM in DMSO
Smiles
CN1C=CC2=C1C=CC(CNC(N3CC4(CC(C(C=CC(F)=C5)=C5O4)=O)C3)=O)=C2
Molecular Formula
C22H20FN3O3
Molecular Weight
393.41
References & Citations
[1]Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560) . Journal of Medicinal Chemistry. 2023 Nov.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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