RGH-560

• Description:

  RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1].

• UNSPSC:

  12352005

• Target:

  NAChR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/rgh-560.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1C=CC2=C1C=CC(CNC(N3CC4(CC(C(C=CC(F)=C5)=C5O4)=O)C3)=O)=C2

• Molecular Formula:

  C22H20FN3O3

• Molecular Weight:

  393.41

• References & Citations:

  [1]Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560) . Journal of Medicinal Chemistry. 2023 Nov.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2408799-43-7]