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TLR7 agonist 18

CAT: 0804-HY-162116Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162116Size:1 Each
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Description
TLR7 agonist 18 (Compound 21a) is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 7.8 μM. TLR7 agonist 18 is not cytotoxic to hTLR7 cotransfected HEK293 cell lines and can induce the secretion of several cytokines, including IL-1β, IL-12p70, IL-8, and TNF-α. TLR7 agonist 18 can be used in vaccine, asthma, allergy and anti-cancer research[1].
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-18.html
Solubility
10 mM in DMSO
Smiles
FC(C1=NC(N2CC(C)CCC2)=C3C(ON=C3C4=CC=C(F)C=C4)=N1)(F)F
Molecular Formula
C18H16F4N4O
Molecular Weight
380.34
References & Citations
[1]Strašek Benedik N, et al. Structural Optimization and Biological Evaluation of Isoxazolo [5, 4-d] pyrimidines as Selective Toll-Like Receptor 7 Agonists[J]. ACS Omega, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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