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Apoptosis inducer 14

CAT: 0804-HY-161098Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161098Size:1 Each
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Description
Apoptosis inducer 14 (Compd 7f), a chemotherapeutic agent, induces intrinsic and extrinsic apoptotic death mediated P53. Apoptosis inducer 14 exhibits IC50 values of 193.93 μg/mL, 6.76 μg/mL and 222.67 μg/mL in A549, HCT116 and HF84 cells, respectively[1].
CAS Number
2750370-67-1
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptosis-inducer-14.html
Solubility
10 mM in DMSO
Smiles
O=C(/C(C#N)=C/C1=CN(C2=CC=CC=C2)N=C1C3=CC=C([N+]([O-])=O)C=C3)C4=CNC5=C4C=CC=C5
Molecular Formula
C27H17N5O3
Molecular Weight
459.46
References & Citations
[1]Magda F Mohamed, et al. Novel 3- (pyrazol-4-yl) -2- (1H-indole-3-carbonyl) acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma. Sci Rep. 2023 Dec 15;13 (1) :22486.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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