Apoptosis inducer 14

• Description:

  Apoptosis inducer 14 (Compd 7f), a chemotherapeutic agent, induces intrinsic and extrinsic apoptotic death mediated P53. Apoptosis inducer 14 exhibits IC50 values of 193.93 μg/mL, 6.76 μg/mL and 222.67 μg/mL in A549, HCT116 and HF84 cells, respectively[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/apoptosis-inducer-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(/C(C#N)=C/C1=CN(C2=CC=CC=C2)N=C1C3=CC=C([N+]([O-])=O)C=C3)C4=CNC5=C4C=CC=C5

• Molecular Formula:

  C27H17N5O3

• Molecular Weight:

  459.46

• References & Citations:

  [1]Magda F Mohamed, et al. Novel 3- (pyrazol-4-yl) -2- (1H-indole-3-carbonyl) acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma. Sci Rep. 2023 Dec 15;13 (1) :22486.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2750370-67-1