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BI 1265162

CAT: 0804-HY-161085Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161085Size:1 Each
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Description
BI 1265162 is a potent inhibitor of endothelial sodium channel (ENaC) that plays an important role in cystic fibrosis research[1].
CAS Number
3042822-44-3
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bi-1265162.html
Solubility
10 mM in DMSO
Smiles
ClC1=CN=C(N)C(C(NCC2=[N+](CC)C(C=CC(OCC(NCCOCP(C)(C)=O)=O)=C3)=C3N2CC)=O)=N1.[O-]P(O)(O)=O
Molecular Formula
C24H36ClN7O9P2
Molecular Weight
663.98
References & Citations
[1]Bodo Betzemeier, et al. Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis. European Journal of Medicinal Chemistry, 2023, 116038, ISSN 0223-5234
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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