BI 1265162

• Description:

  BI 1265162 is a potent inhibitor of endothelial sodium channel (ENaC) that plays an important role in cystic fibrosis research[1].

• UNSPSC:

  12352005

• Target:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/bi-1265162.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CN=C (N) C (C (NCC2=[N+] (CC) C (C=CC (OCC (NCCOCP (C) (C) =O) =O) =C3) =C3N2CC) =O) =N1.[O-]P (O) (O) =O

• Molecular Formula:

  C24H36ClN7O9P2

• Molecular Weight:

  663.98

• References & Citations:

  [1]Bodo Betzemeier, et al. Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis. European Journal of Medicinal Chemistry, 2023, 116038, ISSN 0223-5234

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  3042822-44-3