BI 1265162

• Description :

  BI 1265162 is a potent inhibitor of endothelial sodium channel (ENaC) that plays an important role in cystic fibrosis research[1].

• UNSPSC :

  12352005

• Target :

  Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/bi-1265162.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=CN=C(N)C(C(NCC2=[N+](CC)C(C=CC(OCC(NCCOCP(C)(C)=O)=O)=C3)=C3N2CC)=O)=N1.[O-]P(O)(O)=O

• Molecular Formula :

  C24H36ClN7O9P2

• Molecular Weight :

  663.98

• References & Citations :

  [1]Bodo Betzemeier, et al. Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis. European Journal of Medicinal Chemistry, 2023, 116038, ISSN 0223-5234

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [3042822-44-3]