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PARP/EZH2-IN-2

CAT: 0804-HY-161083Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161083Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARP/EZH2-IN-2 (compound 12e) is a dual target PARP1 and EZH2 inhibitor, with IC50 values of 6.89 and 27.34 nM, respectively. PARP/EZH2-IN-2 shows anticancer activity, with no toxicity to normal cells. PARP/EZH2-IN-2 achieves synthetic lethality indirectly by inhibiting EZH2 to increase the sensitivity to PARP1, and induces cell death by regulating excessive autophagy[1].
UNSPSC
12352005
Target
Histone Methyltransferase; PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp-ezh2-in-2.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(C)=C(C(N1)=O)CNC(C2=CC(C3=CC=C(C4=NC5=C(C(N)=O)C=CC=C5N4)C=C3)=CC6=C2C=NN6C(C)C)=O
Molecular Formula
C33H31N7O3
Molecular Weight
573.64
References & Citations
[1]Li X, et al. Dual target PARP1/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy. Eur J Med Chem. 2023 Dec 17;265:116054.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2; PARP1

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