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PARP-2-IN-3

CAT: 0804-HY-151625-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151625-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARP-2-IN-3 (Compound 12) is a potent PARP-2 inhibitor with an IC50 of 0.07 μM. PARP-2-IN-3 induces apoptosis and necrosis in cancer cells. PARP-2-IN-3 shows appropriate predicted pharmacokinetic parameters and oral bioavailability[1].
CAS Number
2915650-86-9
UNSPSC
12352005
Target
Apoptosis; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp-2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=NC3=CC(Cl)=CC=C3O2)C=C1)CCN4CCOCC4
Molecular Formula
C20H20ClN3O3
Molecular Weight
385.84
References & Citations
[1]El-Ghobashy NM, et al. Synthesis, biological evaluation, and molecular modeling studies of new benzoxazole derivatives as PARP-2 inhibitors targeting breast cancer. Sci Rep. 2022 Sep 28;12 (1) :16246.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP2

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Alternative Products

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BUP02242-01PARP-2-IN-3
sc-393310PARP-2 (F-3)
590423PARP-2
sc-393310 PPARP-2 (F-3) P
sc-393310 FITCPARP-2 (F-3) FITC
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sc-393310 PEPARP-2 (F-3) PE
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