TDI-8304

• Description :

  TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes[1].

• CAS Number :

  [2307262-96-8]

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/tdi-8304.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1[C@@H](N2C(CCC2)=O)CC3=CC=CC(OCCCC[C@H](NC([C@@H](N1)CCN4CCOCC4)=O)C(NC5CCCC5)=O)=C3

• Molecular Formula :

  C32H47N5O6

• Molecular Weight :

  597.75

• References & Citations :

  [1]Hao-Chi Hsu, et al. Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun. 2023 Dec 14;14 (1) :8302.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported