TDI-8304

• Description:

  TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes[1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/tdi-8304.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1[C@@H](N2C(CCC2)=O)CC3=CC=CC(OCCCC[C@H](NC([C@@H](N1)CCN4CCOCC4)=O)C(NC5CCCC5)=O)=C3

• Molecular Formula:

  C32H47N5O6

• Molecular Weight:

  597.75

• References & Citations:

  [1]Hao-Chi Hsu, et al. Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun. 2023 Dec 14;14 (1) :8302.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2307262-96-8]