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TDI-8304

CAT: 0804-HY-161079Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161079Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes[1].
CAS Number
2307262-96-8
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tdi-8304.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H](N2C(CCC2)=O)CC3=CC=CC(OCCCC[C@H](NC([C@@H](N1)CCN4CCOCC4)=O)C(NC5CCCC5)=O)=C3
Molecular Formula
C32H47N5O6
Molecular Weight
597.75
References & Citations
[1]Hao-Chi Hsu, et al. Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun. 2023 Dec 14;14 (1) :8302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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