TDI-015051

CAT: 0931-MF-0113151-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0113151-01Size:10 mg
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CAS Number
3052313-73-9
Target
DNA Methyltransferase|||SARS-CoV
Related Pathways
Microbiology/Virology|||Chromatin/Epigenetic
Bioactivity
TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ?0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM) . Additionally, TDI-015051 suppresses other coronaviruses such as ?-hCoV-NL63, ?-hCoV-229E, and ?-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.
Smiles
O=C(NCC=1C(F)=CC=C2OC=CC21)C3=CC(=C(N3C)C)S(=O)(=O)N4CC=5C=NNC5CC4
Molecular Formula
C22H22FN5O4S
Molecular Weight
471.505
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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