8304-vs

CAT: 0804-HY-156105Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-156105Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8304-vs is a macrocyclic anti-Plasmodial agent that covalently and irreversibly targets the Plasmodium proteasome. 8304-vs effectively inhibits the growth of Plasmodium falciparum[1].
UNSPSC
12352005
Target
Parasite; Proteasome
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/8304-vs.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCC1)[C@@H](CC2=CC(OCCCC[C@H](N3)C(N[C@H](/C=C/S(C)(=O)=O)CC(C)C)=O)=CC=C2)C(N[C@H](C3=O)CCN4CCOCC4)=O
Molecular Formula
C35H53N5O8S
Molecular Weight
703.89
References & Citations
[1]Bennett JM, et al. Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS Infect Dis. 2023 Sep 15..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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