8304-vs

• Description:

  8304-vs is a macrocyclic anti-Plasmodial agent that covalently and irreversibly targets the Plasmodium proteasome. 8304-vs effectively inhibits the growth of Plasmodium falciparum[1].

• UNSPSC:

  12352005

• Target:

  Parasite; Proteasome

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/8304-vs.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(CCC1)[C@@H](CC2=CC(OCCCC[C@H](N3)C(N[C@H](/C=C/S(C)(=O)=O)CC(C)C)=O)=CC=C2)C(N[C@H](C3=O)CCN4CCOCC4)=O

• Molecular Formula:

  C35H53N5O8S

• Molecular Weight:

  703.89

• References & Citations:

  [1]Bennett JM, et al. Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS Infect Dis. 2023 Sep 15..

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported