RegisterLogin

TDI-012804

CAT: 0804-HY-173349Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173349Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids (EC50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids[1].
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
COC1=C(C(NC2=CC=C(C(NC(C3=CC=C(C(O)(C)C)C=C3)=N4)=O)C4=C2)=O)C=NC(C5=CC=CC=C5)=C1
Molecular Formula
C30H26N4O4
Molecular Weight
506.55
References & Citations
[1]Jill Zimmerman, et al. A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression. bioRxiv.2025 Mar 7:2025.03.04.641305.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-164288-01TDI-6570
HY-121815TDI-2760
HY-151798-01TDI-11861
HY-132298-01TDI-10229
HY-178025TDI-014925
HY-162350-01TDI-11055
HY-161079TDI-8304
HY-144330-01TDI-6118
HY-150042-01TDI-011536
HY-170524TDI-015051

Alternative Products

CatalogName
T206709-01TDI-012804
BA5085-25TDI-10229
M35339-01TDI-011536
T204648-01TDI-015051
T87946-01TDI-11055
8036/5TDI 11861
BA5088-5.1TDI-11861
M16824-01TDI-2760
T87499-01TDI-8304
A13959-50TDI-011536 50mg

Popular Products