TDI-012804

• Description:

  TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids (EC50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids[1].

• UNSPSC:

  12352005

• Target:

  PARP

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  COC1=C(C(NC2=CC=C(C(NC(C3=CC=C(C(O)(C)C)C=C3)=N4)=O)C4=C2)=O)C=NC(C5=CC=CC=C5)=C1

• Molecular Formula:

  C30H26N4O4

• Molecular Weight:

  506.55

• References & Citations:

  [1]Jill Zimmerman, et al. A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression. bioRxiv.2025 Mar 7:2025.03.04.641305.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported