T-1-DOCA

CAT: 0804-HY-161045Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-161045Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

T-1-DOCA ia a EGFR inhibitor, with the IC50 of 56.94 and 269.01 nM for EGFRWT and EGFRT790M, respectively. T-1-DOCA can induces cell apoptosis of HCT-116 cells[1].

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/t-1-doca.html

Solubility

10 mM in DMSO

Smiles

O=C(C(N(C)C=N1)=C1N2C)N(CC(NC3=C(Cl)C=CC=C3Cl)=O)C2=O

Molecular Formula

C15H13Cl2N5O3

Molecular Weight

382.20

References & Citations

[1]Eissa IH, et al. Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer. Evol Bioinform Online. 2023;19:11769343231217916. Published 2023 Dec 1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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