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Pomalidomide-C2-amide-C5-azide

CAT: 0804-HY-160235Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160235Size:1 Each
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Description
Pomalidomide-C2-amide-C5-azidea is an E3 linker conjugate, pomalidomide, that can be used to synthesize highly effective PROTAC molecules towards CDK9. Pomalidomide-C2-amide-C5-azidea has antiproliferative activity[1].
CAS Number
2732859-29-7
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-c2-amide-c5-azide.html
Solubility
10 mM in DMSO
Smiles
[N-]=[N+]=NCCCCCC(NCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)=O
Molecular Formula
C21H25N7O5
Molecular Weight
455.47
References & Citations
[1]Xiaqiu Qiu, et al. Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion. Eur J Med Chem. 2021.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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