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Pomalidomide-C5-Dovitinib

CAT: 0931-T81421-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T81421-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2732969-67-2
Target
PDGFR, c-Kit, c-Fms, PROTACs, FLT, Apoptosis, VEGFR, FGFR
Related Pathways
Apoptosis, PROTAC, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC linking Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in FLT3-ITD+ acute myeloid leukemia (AML) cells. It promotes ubiquitin-proteasome-dependent degradation of FLT3-ITD and KIT proteins, thereby inhibiting their downstream signaling pathways and presenting research potential in FLT3-ITD+ AML [1].
Smiles
O=C1NC=2C=CC=C(F)C2C(N)=C1C3=NC4=CC=C(C=C4N3)N5CCN(C(=O)CCCCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5
Molecular Formula
C39H38FN9O6
Molecular Weight
747.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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