BAY-9683

• Description:

  BAY-9683 is an orally active covalent PPARG inverse agonist. BAY-9683 can be used in the study of diseases with overactive PPARG, such as luminal bladder cancer[1].

• UNSPSC:

  12352005

• Target:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bay-9683.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC (N2CCOCC2) =CN=C1NC (C3=C (Cl) C=C (F) C (C (NCC4=CC=C (F) C (F) =C4) =O) =C3) =O

• Molecular Formula:

  C25H22ClF3N4O3

• Molecular Weight:

  518.92

• References & Citations:

  [1]Orsi DL, et al. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg Med Chem. 2023 Jan 15;78:117130.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2891706-83-3