BAY-155

• UNSPSC Description:

  BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM. BAY-155 leads to a strong expression down-regulation of the MEIS1 gene and up-regulation of CD11b and MNDA genes. BAY-155 shows anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models[1].

• Target Antigen:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bay-155.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N)CN1C(C#N)=CC2=C1C=CC(CN(CC3)CCC43CN(C5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)C4)=C2C

• Molecular Weight:

  567.63

• References & Citations:

  [1]Brzezinka K, et al. Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target. Cancers (Basel). 2020 Jan 14;12(1):201.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2163769-52-4