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BAY-155

CAT: 0804-HY-160018Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-160018Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM. BAY-155 leads to a strong expression down-regulation of the MEIS1 gene and up-regulation of CD11b and MNDA genes. BAY-155 shows anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models[1].
CAS Number
[2163769-52-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-155.html
Solubility
10 mM in DMSO
Smiles
O=C(N)CN1C(C#N)=CC2=C1C=CC(CN(CC3)CCC43CN(C5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)C4)=C2C
Molecular Formula
C28H28F3N7OS
Molecular Weight
567.63
References & Citations
[1]Brzezinka K, et al. Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target. Cancers (Basel) . 2020 Jan 14;12 (1) :201.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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