BAY-155

• Description :

  BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM. BAY-155 leads to a strong expression down-regulation of the MEIS1 gene and up-regulation of CD11b and MNDA genes. BAY-155 shows anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bay-155.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N)CN1C(C#N)=CC2=C1C=CC(CN(CC3)CCC43CN(C5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)C4)=C2C

• Molecular Formula :

  C28H28F3N7OS

• Molecular Weight :

  567.63

• References & Citations :

  [1]Brzezinka K, et al. Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target. Cancers (Basel) . 2020 Jan 14;12 (1) :201.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2163769-52-4]