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EGFR-IN-155

CAT: 0804-HY-173314Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173314Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-155 (compound 13a) is an EGFR inhibitor with IC50 values of 0.14 nM and 0.18 nM against EGFR TK and EGFR L858R, respectively. EGFR-IN-155 inhibits tumor growth, causes a cell cycle arrest at S phase, and and induces cell apoptosis[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=NC(OC2=CC=C(C=C2)/C=N/NC3=CC=CC=C3)=C4C=C(OC)C(OC)=CC4=N1
Molecular Formula
C24H22N4O3
Molecular Weight
414.46
References & Citations
[1]Saleh NS, et al. 6,7-Dimethoxy-2-methyl-4-substituted quinazolines: Design, synthesis, EGFR inhibitory activity, in vitro cytotoxicity, and in silico studies. Eur J Med Chem. 2025 Jun 5;290:117502.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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