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DHX9-IN-16

CAT: 0804-HY-157612Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157612Size:1 Each
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Description
DHX9-IN-16 (208) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.125 μM in DHX9 cellular target engagement. Used in cancer research[1].
CAS Number
2973397-48-5
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhx9-in-16.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=NC=C(C=N2)OCC)C(C)=C1)NC3=CC(Cl)=CC(NS(=O)(C)=O)=C3
Molecular Formula
C19H20ClN5O4S
Molecular Weight
449.91
References & Citations
[1]Matthew H, et al.Matthew H, et al. Inhibitors of rna helicase dhx9 and uses thereof. Patent WO2023154519. Inhibitors of rna helicase dhx9 and uses thereof. Patent WO2023154519.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dhx9-IN-16
CAS Number2973397-48-5
PubChem CID170836258
IUPAC NameN-[3-chloro-5-(methanesulfonamido)phenyl]-1-(5-ethoxypyrimidin-2-yl)-5-methylpyrrole-3-carboxamide
Molecular FormulaC19H20ClN5O4S
Molecular Weight449.9
XLogP2.1
Topological Polar Surface Area124
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity683
SMILES
CCOC1=CN=C(N=C1)N2C=C(C=C2C)C(=O)NC3=CC(=CC(=C3)Cl)NS(=O)(=O)C
InChI
InChI=1S/C19H20ClN5O4S/c1-4-29-17-9-21-19(22-10-17)25-11-13(5-12(25)2)18(26)23-15-6-14(20)7-16(8-15)24-30(3,27)28/h5-11,24H,4H2,1-3H3,(H,23,26)
InChIKey
SRAYPGGVNBQVPD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dhx9-IN-16
CAS: 2973397-48-5
CID: 170836258
Formula: C19H20ClN5O4S
MW: 449.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight449.9
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass449.0924530
Monoisotopic Mass449.0924530
Topological Polar Surface Area124 Ų
Heavy Atom Count30
Formal Charge0
Complexity683
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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