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DHX9-IN-13

CAT: 0804-HY-157606Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157606Size:1 Each
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Description
DHX9-IN-13 (389) is a RNA helicase DHX9 inhibitor, with an EC50 of 3.4 μM in DHX9 cellular target engagement. Used in cancer research[1].
CAS Number
2973399-28-7
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhx9-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=NC=C(C=C2)Cl)C(C)=C1)NC3=CC(Cl)=CC(NS(=O)(C)=O)=C3
Molecular Formula
C18H16Cl2N4O3S
Molecular Weight
439.32
References & Citations
[1]Matthew H, et al. Inhibitors of rna helicase dhx9 and uses thereof. Patent WO2023154519.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dhx9-IN-13
CAS Number2973399-28-7
PubChem CID170836256
IUPAC NameN-[3-chloro-5-(methanesulfonamido)phenyl]-1-(5-chloro-2-pyridinyl)-5-methylpyrrole-3-carboxamide
Molecular FormulaC18H16Cl2N4O3S
Molecular Weight439.3
XLogP3
Topological Polar Surface Area101
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity660
SMILES
CC1=CC(=CN1C2=NC=C(C=C2)Cl)C(=O)NC3=CC(=CC(=C3)Cl)NS(=O)(=O)C
InChI
InChI=1S/C18H16Cl2N4O3S/c1-11-5-12(10-24(11)17-4-3-13(19)9-21-17)18(25)22-15-6-14(20)7-16(8-15)23-28(2,26)27/h3-10,23H,1-2H3,(H,22,25)
InChIKey
WPKNHRQCPRFXDI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dhx9-IN-13
CAS: 2973399-28-7
CID: 170836256
Formula: C18H16Cl2N4O3S
MW: 439.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight439.3
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass438.0320169
Monoisotopic Mass438.0320169
Topological Polar Surface Area101 Ų
Heavy Atom Count28
Formal Charge0
Complexity660
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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