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DHX9-IN-15

CAT: 0804-HY-157607Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157607Size:1 Each
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Description
DHX9-IN-15 (287) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.232 μM in DHX9 cellular target engagement. Used in cancer research[1].
CAS Number
2973398-27-3
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhx9-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=NC=CC=C2)C(C(C)O)=C1)NC3=CC(Cl)=CC(NS(=O)(C)=O)=C3
Molecular Formula
C19H19ClN4O4S
Molecular Weight
434.90
References & Citations
[1]Matthew H, et al. Inhibitors of rna helicase dhx9 and uses thereof. Patent WO2023154519.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dhx9-IN-15
CAS Number2973398-27-3
PubChem CID170836257
IUPAC NameN-[3-chloro-5-(methanesulfonamido)phenyl]-5-(1-hydroxyethyl)-1-pyridin-2-ylpyrrole-3-carboxamide
Molecular FormulaC19H19ClN4O4S
Molecular Weight434.9
XLogP1.6
Topological Polar Surface Area122
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity674
SMILES
CC(C1=CC(=CN1C2=CC=CC=N2)C(=O)NC3=CC(=CC(=C3)Cl)NS(=O)(=O)C)O
InChI
InChI=1S/C19H19ClN4O4S/c1-12(25)17-7-13(11-24(17)18-5-3-4-6-21-18)19(26)22-15-8-14(20)9-16(10-15)23-29(2,27)28/h3-12,23,25H,1-2H3,(H,22,26)
InChIKey
SRFBAIRGLATLGS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dhx9-IN-15
CAS: 2973398-27-3
CID: 170836257
Formula: C19H19ClN4O4S
MW: 434.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight434.9
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass434.0815540
Monoisotopic Mass434.0815540
Topological Polar Surface Area122 Ų
Heavy Atom Count29
Formal Charge0
Complexity674
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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