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DHX9-IN-10

CAT: 0804-HY-157608Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157608Size:1 Each
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Description
DHX9-IN-10 (49) is a RNA helicase DHX9 inhibitor, with an EC50 of 9.04 μM in DHX9 cellular target engagement. Used in cancer research[1].
CAS Number
2973746-79-9
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhx9-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C2=CC=CC=C2)=C(C)S1)NC3=CC=CC(NS(=O)(C)=O)=C3
Molecular Formula
C19H18N2O3S2
Molecular Weight
386.49
References & Citations
[1]Matthew H. Daniels, et al. Inhibitors of rna helicase dhx9 and uses thereof. Patent WO2023158795.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dhx9-IN-10
CAS Number2973746-79-9
PubChem CID169152085
IUPAC NameN-[3-(methanesulfonamido)phenyl]-5-methyl-4-phenylthiophene-2-carboxamide
Molecular FormulaC19H18N2O3S2
Molecular Weight386.5
XLogP3.8
Topological Polar Surface Area112
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity584
SMILES
CC1=C(C=C(S1)C(=O)NC2=CC(=CC=C2)NS(=O)(=O)C)C3=CC=CC=C3
InChI
InChI=1S/C19H18N2O3S2/c1-13-17(14-7-4-3-5-8-14)12-18(25-13)19(22)20-15-9-6-10-16(11-15)21-26(2,23)24/h3-12,21H,1-2H3,(H,20,22)
InChIKey
KZMYWFWZPAXWOI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dhx9-IN-10
CAS: 2973746-79-9
CID: 169152085
Formula: C19H18N2O3S2
MW: 386.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.5
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass386.07588479
Monoisotopic Mass386.07588479
Topological Polar Surface Area112 Ų
Heavy Atom Count26
Formal Charge0
Complexity584
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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