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AChE/BChE-IN-16

CAT: 0804-HY-157437Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157437Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC50s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H2O2-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS) [1].
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-16.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCCCCNC1=C(C=CC(F)=C2)C2=NC3=C1CCCC3)OC4=CC=C(C(N5)=CC6=C5N=CC=C6)C=C4
Molecular Formula
C33H34FN5O2
Molecular Weight
551.65
References & Citations
[1]Yaoyang Liu, et al. Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 Dec 21:265:116071
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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