HLDA-221

• Description :

  HLDA-221 is a heterobifunctional small molecules called Regulated Induced Proximity Targeting Chimeras (RIPTACs) . HLDA-221 elicits a stable ternary complex between a target protein selectively expressed in cancer tissue and a pan-expressed protein essential for cell survival, thus leading to cell death selectively in cells expressing the target protein[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hlda-221.html

• Concentration :

  10mM

• Purity :

  99.24

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  CC(C(C(C(C=C1)=CC=C1Cl)=N[C@H]2CC(NCCOCCOCCN(C(COC3=CC=CC([C@@H](CCC4=CC(OC)=C(OC)C=C4)OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)=C3)=O)C)=O)=C(S7)N8C2=NN=C8C)=C7C

• Molecular Formula :

  C64H78ClN7O13S

• Molecular Weight :

  1220.86

• References & Citations :

  [1]Kanak Raina, et al. Regulated Induced Proximity Targeting Chimeras (RIPTACs) : a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively. bioRxiv. 2023 Jan 2:2023.01.01.522436.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3077339-82-0]